Valis: The Fantasm Soldier (Genesis / Mega Drive)

Good old anime that pits a typical high school girl that just wants to live a normal high school life against a world full of magic, fantasy, and evil.  Valis was one such game to do this on the Genesis, and arguably the most popular one to do so.  Tight controls, interesting enemies, and this anime-inspired theme were prevalent throughout the game as Yuko attempted to fulfill her destiny as the Valis warrior.