Vice - Project Doom (NES / Famicom)

While Bayou Billy may get the most attention for combining a bunch of different genres in a single game on the NES, there were other titles that also did this.  One of my favorite of the bunch was Vice: Project Doom where you played some mysterious guy fighting a mysterious enemy.  The game had driving, shooting, and side-scrolling action.  Stick that in your pipe and smoke it, Konami.